Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma
نویسندگان
چکیده
منابع مشابه
Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma
NKL homeobox genes are basic regulators of cell and tissue differentiation, many acting as oncogenes in T-cell leukemia. Recently, we described an hematopoietic NKL-code comprising six particular NKL homeobox genes expressed in hematopoietic stem cells and lymphoid progenitors, unmasking their physiological roles in the development of these cell types. Hodgkin lymphoma (HL) is a B-cell malignan...
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In Hodgkin lymphoma (HL) we recently identified deregulated expression of homeobox genes MSX1 and OTX2 which are physiologically involved in development of the embryonal neural plate border region. Here, we examined in HL homeobox gene SIX1 an additional regulator of this embryonal region mediating differentiation of placodal precursors. SIX1 was aberrantly activated in 12 % of HL patient sampl...
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Immunohistochemical analysis of skin tissue biopsies from an individual with acute graft-versus-host-disease. Scattered ICOS+ activated lymphocytes were observed at the dermo-epidermal junction, superficial dermis and around the adnexal follicular epithelium. Figure taken from the article by Maria Cuzzola and colleagues on page 1532. Widespread over-expression of the non-clustered homeobox gene...
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Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods:...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.24512